Link with more information: https://iupac.org/100/pt-of-chemist/#thomas-hermans-fr
Chemically fuelled processes control size oscillations of natural fibres inside the body such as microtubules or actin filaments. Researchers from the University of Strasbourg have now discovered similar size oscillations in a completely artificial system. Brightly coloured molecules form extended supramolecular fibres that can be controlled by redox chemistry. In a continuous flow system, these fibres grow and shrink spontaneously. Self-oscillating artificial systems provide a stepping stone to life-like materials with applications in material science, medicine, and soft robotics. The results have been published in Nature Nanotechnology.
Living organisms use chemical fuels like guanosine triphosphate (GTP) to drive assembly and disassembly processes of fibres in the cytoskeleton. Microtubules for example are formed by tubulin bound to GTP, which self-assembles into long fibres. Once the fuel is consumed, which for microtubules is when GTP is hydrolysed to guanosine diphosphate GDP, the fibres disappear. Inside the cell such fibres can show spontaneous size oscillations, which serve to maintain the cytoskeleton and its functions.
Now researchers from the University of Strasbourg (France) and Aston University (UK) have developed a completely artificial system that works similarly to microtubules. They developed a molecule that can form fibres spontaneously through self-assembly, starting from small nuclei that rapidly grow. The molecule can be deactivated by reacting with a chemical reductant, which causes the fibres to disassemble. The molecules can be reactivated by oxygen (an oxidant), which makes the fibres grow again. In addition to spontaneous oscillations, the researchers have observed traveling waves of fibre formation, and intricate centimetre-scale patterns. They found that the interplay of self-assembly and fluid convection, leads to these mosaic-like structures. Overall, the work opens new pathways to obtain life-like artificial systems and materials, which can perform complex biological functions such as cell division in the future.
J.Leira-Iglesias, A.Tassoni, T.Adachi, M.Stich, T.M.Hermans
Oscillations, traveling fronts and patterns in a supramolecular system, Nature Nanotechnology 2018
The ERC Starting Grant proposal “Life-Cycle” has been awarded. Here is the list of awardees: https://erc.europa.eu/…/do…/file/erc_2017_stg_results_pe.pdf
See the dedicated page for more info.
This multidisciplinary network entitled: “Magnetics and Microhydrodynamics – from guided transport to delivery” (MaMi) bridges the research fields of fluidics and magnetism, by taking advantage of magnetic forces to control local flows and cargo transport inspired by biomimetic systems. Using magnetic sources, as well as high magnetic susceptibility liquids or nanostructures, devices with unique anti-fouling properties and non-slip boundary conditions can be realized. Three PhD positions have been assigned in Strasbourg (application process is closed).Muthulakshmi Sengottuvel will be joining our team in October.
Congratulations to Prof. Jean-Pierre Sauvage!!! He is joining Prof. Jean-Marie Lehn and Prof. Martin Karplus to become a Nobel Laureate in Chemistry. Three Nobel and one Kavli laureate at ISIS!
Welcome to Takuji Adachi (postdoc) and Lafayette de Windt (M2) who both started on August 16th.
Mathieu is joining us as a summer student (L2), working with Nathan Fuchs (M2).
This year we’ll have the pleasure to work with:
- Guillaume Poss (M2)
- Nathan Fuchs (M2)
- Mohamed Raoui (M1)
- Sicen Liu (M1)
- Aghawidya Adipatria (M1)